Fluorous chiral bisoxazolines: application in copper-catalyzed asymmetric α-hydrophosphonylation.
نویسندگان
چکیده
A copper-catalyzed asymmetric α-hydrophosphonylation of isatins with a novel fluorous bis(oxazoline) as a ligand is presented. The corresponding chiral α(1)-oxindole-α-hydroxyphosphonates were obtained in 30-91% yield with enantioselectivities up to 92%. The fluorous ligand can be easily recovered and reused at least 3 times without a significant loss in its activity.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 31 شماره
صفحات -
تاریخ انتشار 2014